Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases

@inproceedings{Lotsari2012BreastCA,
  title={Breast carcinoma and Lynch syndrome: molecular analysis of tumors arising in mutation carriers, non-carriers, and sporadic cases},
  author={Johanna E Lotsari and Annette Gylling and Wael M Abdel-Rahman and Taina Tuulikki Nieminen and Kristiina Aittom{\"a}ki and Marjukka Friman and Reino Pitk{\"a}nen and Markku T Aarnio and Heikki J{\"a}rvinen and Jukka-Pekka Mecklin and Teijo H Kuopio and P{\"a}ivi Peltom{\"a}ki},
  booktitle={Breast Cancer Research},
  year={2012}
}
Breast carcinoma is the most common cancer in women, but its incidence is not increased in Lynch syndrome (LS) and studies on DNA mismatch repair deficiency (MMR) in LS-associated breast cancers have arrived at conflicting results. This study aimed to settle the question as to whether breast carcinoma belongs to the LS tumor spectrum. MMR status and epigenetic profiles were determined for all available breast carcinomas identified among 200 LS families from a nation-wide registry (23 tumors… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 5 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 20 extracted citations

Update on Lynch syndrome genomics

Familial Cancer • 2016
View 4 Excerpts

References

Publications referenced by this paper.
Showing 1-10 of 55 references

Colorectal and other cancer risks for carriers and noncarriers from families with a DNA mismatch repair gene mutation: a prospective cohort study.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology • 2012
View 1 Excerpt

Lynch syndrome-associated breast cancers: clinicopathologic characteristics of a case series from the colon cancer family registry.

Clinical cancer research : an official journal of the American Association for Cancer Research • 2010

Risks of Lynch syndrome cancers for MSH6 mutation carriers.

Journal of the National Cancer Institute • 2010
View 1 Excerpt

Similar Papers

Loading similar papers…