Breast cancers with high DSS1 expression that potentially maintains BRCA2 stability have poor prognosis in the relapse-free survival

@inproceedings{Rezano2013BreastCW,
  title={Breast cancers with high DSS1 expression that potentially maintains BRCA2 stability have poor prognosis in the relapse-free survival},
  author={Andri Rezano and Kazuhiko Kuwahara and Mutsuko Yamamoto-Ibusuki and Masahiro Kitabatake and Penpak Moolthiya and Suchada Phimsen and Taiji Suda and Shigenobu T{\'o}ne and Yutaka Yamamoto and Hirotaka Iwase and Nobuo Sakaguchi},
  booktitle={BMC Cancer},
  year={2013}
}
Genetic BRCA2 insufficiency is associated with breast cancer development; however, in sporadic breast cancer cases, high BRCA2 expression is paradoxically correlated with poor prognosis. Because DSS1, a mammalian component of the transcription/RNA export complex, is known to stabilize BRCA2, we investigated how the expression of DSS1 is associated with clinical parameters in breast cancers. DSS1 mRNA and p53 protein were examined by RT-PCR and immunohistochemical staining of breast cancer… CONTINUE READING
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