Breast cancer susceptibility testing: past, present and future.

  title={Breast cancer susceptibility testing: past, present and future.},
  author={Jessica I. Goldberg and Patrick Ivan Borgen},
  journal={Expert review of anticancer therapy},
  volume={6 8},
Breast cancer is a genetic disease. The cancer phenotype is defined by a complex interplay between oncogenes, tumor-suppressor genes and epigenetic factors. Only 5-10% of all breast cancers can be attributed to one of several breast cancer familial syndromes, the most common of which is the hereditary breast and ovarian syndrome caused by deleterious mutations of the BRCA1 or BRCA2 tumor-suppressor genes. The functions of the BRCA proteins are not fully understood, although it is clear that… CONTINUE READING