Breast cancer subtypes express distinct receptor repertoires for tumor-associated macrophage derived cytokines.

@article{Levano2011BreastCS,
  title={Breast cancer subtypes express distinct receptor repertoires for tumor-associated macrophage derived cytokines.},
  author={Kelly S Levano and Eric H Jung and Paraic A. Kenny},
  journal={Biochemical and biophysical research communications},
  year={2011},
  volume={411 1},
  pages={107-10}
}
Infiltration of the tumor microenvironment by macrophages is associated with poor outcomes in breast cancer and other solid tumors, however the identity and roles of many of the soluble factors these macrophages produce remains to be elucidated in detail. In addition to producing angiogenic factors (e.g. VEGF), proteases (e.g. MMP9) and immunomodulatory factors (e.g. IL10) which, by modifying the local microenvironment, likely contribute to progression in the majority of solid tumors, we have… CONTINUE READING
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