Breast cancer risk reduction and membrane-bound catechol O-methyltransferase genetic polymorphisms.

@article{Ji2008BreastCR,
  title={Breast cancer risk reduction and membrane-bound catechol O-methyltransferase genetic polymorphisms.},
  author={Yuan Ji and Janet L. Olson and Jianping Zhang and Michelle Hildebrandt and Liewei Wang and James N. Ingle and Zachary S. Fredericksen and Thomas A. Sellers and William Miller and J Michael J Dixon and Hiltrud Brauch and Michel Eichelbaum and Christina Justenhoven and Ute Hamann and Yon D. Ko and Thomas Bruening and Jenny Chang-Claude and Shan Wang-gohrke and Daniel J. Schaid and Richard M. Weinshilboum},
  journal={Cancer research},
  year={2008},
  volume={68 14},
  pages={5997-6005}
}
Catechol O-methyltransferase (COMT)-catalyzed methylation of catecholestrogens has been proposed to play a protective role in estrogen-induced genotoxic carcinogenesis. We have taken a comprehensive approach to test the hypothesis that genetic variation in COMT might influence breast cancer risk. Fifteen COMT single nucleotide polymorphisms (SNPs) selected on the basis of in-depth resequencing of the COMT gene were genotyped in 1,482 DNA samples from a Mayo Clinic breast cancer case control… CONTINUE READING
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Mammogrpahic breast density and membrane - bound catecholO - methyltransferase ( COMT ) genetic polymorphisms [ abstract 525 ]

  • JE Olson, Y Ji, CM Vachon
  • Proc Am Assoc Cancer Res
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Mammogrpahic breast density and membrane-bound catechol-Omethyltransferase (COMT) genetic polymorphisms

  • JE Olson, Y Ji, CM Vachon
  • Proc Am Assoc Cancer Res
  • 2008
1 Excerpt

Common variants on chromosomes 2 q 35 and 16 q 12 confer susceptibility to estrogen receptorpositive breast can

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