Breast cancer risk and imprinting methylation in blood

@inproceedings{Harrison2015BreastCR,
  title={Breast cancer risk and imprinting methylation in blood},
  author={Kristina Harrison and Gordon V. Hoad and Paula Scott and Louise Simpson and Graham W. Horgan and Elizabeth A Smyth and Steven D. Heys and Paul Haggarty},
  booktitle={Clinical Epigenetics},
  year={2015}
}
Altered DNA methylation of imprinted genes has been implicated in a range of cancers. Imprinting is established early in development, and some are maintained throughout the life course in multiple tissues, providing a plausible mechanism linking known early life factors to cancer risk. This study investigated methylation status of seven imprinted differentially methylated regions—PLAGL1/ZAC1, H19-ICR1, IGF2-DMR2, KvDMR-ICR2, RB1, SNRPN-DMR1 and PEG3—in blood samples from 189 women with the most… CONTINUE READING
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