Breast cancer risk and clinical implications for germline PTEN mutation carriers

@article{Ngeow2015BreastCR,
  title={Breast cancer risk and clinical implications for germline PTEN mutation carriers},
  author={Joanne Ngeow and Kaitlin M Sesock and Charis Eng},
  journal={Breast Cancer Research and Treatment},
  year={2015},
  volume={165},
  pages={1-8}
}
PTEN Hamartoma Tumor syndrome (PHTS) encompasses a clinical spectrum of heritable disorders including Cowden syndrome (CS), Bannayan–Riley–Ruvalcaba syndrome, and Proteus and Proteus-like syndrome that are associated with germline mutations in the PTEN tumor suppressor gene. Breast cancer risk estimates (67–85 %) for women with germline PTEN mutations are similar to those quoted for patients with germline mutations in the BRCA1/2 genes. With PTEN on several germline gene testing panels, finding… CONTINUE READING
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