Breast cancer resistance protein impacts clinical outcome in platinum-based chemotherapy for advanced non-small cell lung cancer.

@article{Yoh2004BreastCR,
  title={Breast cancer resistance protein impacts clinical outcome in platinum-based chemotherapy for advanced non-small cell lung cancer.},
  author={Kiyotaka Yoh and Genichiro Ishii and Tomoyuki Yokose and Yuji Minegishi and Kohji Tsuta and Koichi Goto and Yutaka Nishiwaki and Tetsuro Kodama and Moritaka Suga and Atsushi Ochiai},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2004},
  volume={10 5},
  pages={1691-7}
}
PURPOSE The purpose of this study was to investigate the relationship between the level of expression of ATP-binding cassette (ABC) transporter proteins, and response to chemotherapy and prognosis in advanced non-small cell lung cancer (NSCLC). EXPERIMENTAL DESIGN Expression of ABC transporter proteins, including P-glycoprotein, multidrug resistance protein (MRP) 1, MRP2, MRP3, and breast cancer resistance protein (BCRP), was examined immunohistochemically in 72 formalin-fixed tumor samples… CONTINUE READING

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