Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1, IQ and Trp-P-1 but also mediates their secretion into breast milk.

@article{Herwaarden2006BreastCR,
  title={Breast cancer resistance protein (Bcrp1/Abcg2) reduces systemic exposure of the dietary carcinogens aflatoxin B1, IQ and Trp-P-1 but also mediates their secretion into breast milk.},
  author={Antonius E. van Herwaarden and E. B. Wagenaar and Barbara N Karnekamp and Gracia Merino and Johan W. Jonker and Alfred H Schinkel},
  journal={Carcinogenesis},
  year={2006},
  volume={27 1},
  pages={123-30}
}
The breast cancer resistance protein (BCRP/ABCG2) usually protects the body from a wide variety of environmental and dietary xenotoxins by reducing their net uptake from intestine and by increasing their hepatobiliary, intestinal and renal elimination. BCRP is also highly expressed in lactating mammary glands in mice, and this expression is conserved in cows and humans. As a result, BCRP substrates can be secreted into milk. We investigated whether different classes of dietary carcinogens are… CONTINUE READING

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