Breast cancer resistance protein (BCRP/ABCG2) localises to the nucleus in glioblastoma multiforme cells.

  title={Breast cancer resistance protein (BCRP/ABCG2) localises to the nucleus in glioblastoma multiforme cells.},
  author={Prateek A Bhatia and Michel Bernier and Mitesh Sanghvi and Ruin Moaddel and Roland S Schwarting and Anuradha Ramamoorthy and Irving W Wainer},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  volume={42 8},
The breast cancer resistance protein (BCRP), an ATP binding cassette (ABC) efflux transporter, plays a role in multiple drug resistance (MDR). Previous studies of the subcellular location of the ABC transporter P-glycoprotein indicated that this protein is expressed in nuclear membranes. This study examines the nuclear distribution of BCRP in seven human-derived glioblastoma (GBM) and astrocytoma cell lines. BCRP expression was observed in the nuclear extracts of 6/7 cell lines. Using the GBM… CONTINUE READING


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