Breast cancer resistance protein: mediating the trans-placental transfer of glyburide across the human placenta.

@article{Gedeon2008BreastCR,
  title={Breast cancer resistance protein: mediating the trans-placental transfer of glyburide across the human placenta.},
  author={Christelle Gedeon and Gregory J. Anger and Micheline Piquette-Miller and Gideon Koren},
  journal={Placenta},
  year={2008},
  volume={29 1},
  pages={
          39-43
        }
}
Members of the ATP-binding cassette (ABC) efflux transporter family, including P-glycoprotein (PGP), the multidrug resistance-associated proteins (MRPs) and the breast cancer resistance protein (BCRP) have been shown to be highly expressed in the human placenta. Recent studies documented that the oral hypoglycemic glyburide does not cross the human placenta to an appreciable extent. Furthermore, the trans-placental transfer of glyburide has been shown not to be affected by either the presence… CONTINUE READING

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