Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks.

@article{Buisson2014BreastCP,
  title={Breast cancer proteins PALB2 and BRCA2 stimulate polymerase η in recombination-associated DNA synthesis at blocked replication forks.},
  author={R{\'e}mi Buisson and Joshi Niraj and Joris Pauty and Ranjan Maity and Weixing Zhao and Yan Coulombe and Patrick Sung and Jean-Yves Masson},
  journal={Cell reports},
  year={2014},
  volume={6 3},
  pages={
          553-64
        }
}
One envisioned function of homologous recombination (HR) is to find a template for DNA synthesis from the resected 3'-OH molecules that occur during double-strand break (DSB) repair at collapsed replication forks. However, the interplay between DNA synthesis and HR remains poorly understood in higher eukaryotic cells. Here, we reveal functions for the breast cancer proteins BRCA2 and PALB2 at blocked replication forks and show a role for these proteins in stimulating polymerase η (Polη) to… CONTINUE READING

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