Breast cancer patients with p53 Pro72 homozygous genotype have a poorer survival.

  title={Breast cancer patients with p53 Pro72 homozygous genotype have a poorer survival.},
  author={Johanna Tommiska and Hannaleena Eerola and Mira Heinonen and Laura Salonen and Milja Kaare and Jonna Tallila and Ari Ristim{\"a}ki and Karl Johan Albert Von Smitten and Kristiina Aittom{\"a}ki and P{\"a}ivi Heikkil{\"a} and Carl Blomqvist and Heli Nevanlinna},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  volume={11 14},
PURPOSE The p53 R72P polymorphism has been suggested to play a role in many cancers, including breast cancer. Our aim was to evaluate association of R72P with breast cancer risk as well as histopathologic features of the breast tumors and survival. EXPERIMENTAL DESIGN The germ line R72P genotype was defined among 939 Finnish familial and 888 unselected breast cancer patients and 736 healthy population controls. The clinical and biological variables were tested for association by univariate… CONTINUE READING
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Correlationof CHEK 2 proteinexpressionandc . 1100 delCmutation status with tumor characteristics among unselectedbreast cancer patients

  • O Kilpivaara, H Eerola
  • IntJCancer
  • 2005

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