Breast cancer normalization induced by embryonic mesenchyme is mediated by extracellular matrix biglycan.

@article{Bischof2013BreastCN,
  title={Breast cancer normalization induced by embryonic mesenchyme is mediated by extracellular matrix biglycan.},
  author={Ashley G. Bischof and Deniz Y{\"u}ksel and Tadanori Mammoto and Akiko Mammoto and Silva Krause and Donald E. Ingber},
  journal={Integrative biology : quantitative biosciences from nano to macro},
  year={2013},
  volume={5 8},
  pages={1045-56}
}
Some epithelial cancers can be induced to revert to quiescent differentiated tissue when combined with embryonic mesenchyme; however, the mechanism of this induction is unknown. Here we combine tissue engineering, developmental biology, biochemistry and proteomics approaches to attack this problem. Using a synthetic reconstitution system, we show that co-culture of breast cancer cells with embryonic mesenchyme from early stage (E12.5-13.5) mammary glands decreases tumor cell proliferation while… CONTINUE READING

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Neoplastic CellIs abnormal cell of diseaseBreast Carcinoma
Using a synthetic reconstitution system , we show that co - culture of breast cancer cells with embryonic mesenchyme from early stage ( E12.5 - 13.5 ) mammary glands decreases tumor cell proliferation while stimulating acinus differentiation , whereas cancer - associated fibroblasts ( CAFs ) fail to produce these normalizing effects .
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