Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis.

@article{Hurst2009BreastCM,
  title={Breast cancer metastasis suppressor 1 up-regulates miR-146, which suppresses breast cancer metastasis.},
  author={Douglas R. Hurst and Mick D. Edmonds and G. Kellam Scott and Christopher C. Benz and Kedar S. Vaidya and Danny R Welch},
  journal={Cancer research},
  year={2009},
  volume={69 4},
  pages={
          1279-83
        }
}
Breast cancer metastasis suppressor 1 (BRMS1) is a predominantly nuclear protein that differentially regulates expression of multiple genes, leading to suppression of metastasis without blocking orthotopic tumor growth in multiple human and murine cancer cells of diverse origins. We hypothesized that miR-146 may be involved in the ability of BRMS1 to supress metastasis because miR-146 expression is altered by BRMS1 and because BRMS1 and miR-146 are both associated with decreased signaling… CONTINUE READING

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