Breast cancer metastasis: challenges and opportunities.

@article{Lu2009BreastCM,
  title={Breast cancer metastasis: challenges and opportunities.},
  author={Jing Lu and Patricia S. Steeg and Janet E. Price and Savitri Krishnamurthy and Sendurai A Mani and James Reuben and Massimo Cristofanilli and Gabriela Dontu and Luc M. Bidaut and Vicente Valero and Gabriel N. Hortobagyi and Dihua Yu},
  journal={Cancer research},
  year={2009},
  volume={69 12},
  pages={
          4951-3
        }
}
Despite exciting progress in the understanding of breast cancer development and progression, and in the development of novel therapeutic strategies, breast cancer remains the second leading cause of cancer-related death in women, with a yearly toll of more than 40,000 deaths in the United States 
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Potential mechanisms of Notch-mediated resistance in breast cancer cells and breast cancer stem cells are discussed, and various methods of targeting Notch through γ-secretase inhibitors, Notch signaling biologics, or transcriptional inhibitors are discussed.
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