Breast cancer lung metastasis requires expression of chemokine receptor CCR4 and regulatory T cells.

@article{Olkhanud2009BreastCL,
  title={Breast cancer lung metastasis requires expression of chemokine receptor CCR4 and regulatory T cells.},
  author={Purevdorj B. Olkhanud and Dolgor Baatar and Monica Bodogai and Fran T. Hakim and Ronald Gress and Robin L Anderson and Jie Deng and Mai Xu and Susanne Briest and Arya Biragyn},
  journal={Cancer research},
  year={2009},
  volume={69 14},
  pages={5996-6004}
}
Cancer metastasis is a leading cause of cancer morbidity and mortality. More needs to be learned about mechanisms that control this process. In particular, the role of chemokine receptors in metastasis remains controversial. Here, using a highly metastatic breast cancer (4T1) model, we show that lung metastasis is a feature of only a proportion of the tumor cells that express CCR4. Moreover, the primary tumor growing in mammary pads activates remotely the expression of TARC/CCL17 and MDC/CCL22… CONTINUE READING

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