Breast cancer heterogeneity: evaluation of clonality in primary and metastatic lesions.

@article{Symmans1995BreastCH,
  title={Breast cancer heterogeneity: evaluation of clonality in primary and metastatic lesions.},
  author={W. Fraser Symmans and Jiangying Liu and Daniel M. Knowles and Giorgio Inghirami},
  journal={Human pathology},
  year={1995},
  volume={26 2},
  pages={210-6}
}
Breast cancers often contain different clones of tumor cells. Attention to the cellular properties of breast cancer metastases may identify characteristics in primary tumors that are associated with metastasis. Such characteristics could include DNA content, cell proliferation, abnormal oncogene expression, or relative cell population (clonal dominance). We examined DNA ploidy (image analysis), proliferation index (proliferating cell nuclear antigen-1 immunostaining), and expression of Her-2… CONTINUE READING

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