Breast cancer growth prevention by statins.

  title={Breast cancer growth prevention by statins.},
  author={M J Campbell and Laura Esserman and Yamei Zhou and Mark Shoemaker and Margaret M Lobo and Elizabeth Borman and Frederick L. Baehner and A. S. Manoj Kumar and Kelly M Adduci and Corina Marx and Emanual F. Petricoin and Lance A. Liotta and Mary J Winters and Stephen Benz and Christopher C. Benz},
  journal={Cancer research},
  volume={66 17},
Statins are cholesterol-lowering drugs with pleiotropic activities including inhibition of isoprenylation reactions and reduction of signals driving cell proliferation and survival responses. The objectives of this study were to examine the effects of statins on breast cancer cells, both in vitro and in vivo, and to begin to determine their mechanism of action. We evaluated the effects of statins on breast cancer cell growth, phosphoprotein signaling intermediates, survival/apoptosis regulators… CONTINUE READING
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