Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases.

@article{Bu2008BreastCD,
  title={Breast cancer-derived Dickkopf1 inhibits osteoblast differentiation and osteoprotegerin expression: implication for breast cancer osteolytic bone metastases.},
  author={Guojun Bu and Wenyan Lu and Chia-Chen Liu and Katri S Selander and Toshiyuki Yoneda and Christopher H. Hall and Evan Keller and Yonghe Li},
  journal={International journal of cancer},
  year={2008},
  volume={123 5},
  pages={1034-42}
}
Most breast cancer metastases in bone form osteolytic lesions, but the mechanisms of tumor-induced bone resorption and destruction are not fully understood. Although it is well recognized that Wnt/beta-catenin signaling is important for breast cancer tumorigenesis, the role of this pathway in breast cancer bone metastasis is unclear. Dickkopf1 (Dkk1) is a secreted Wnt/beta-catenin antagonist. In the present study, we demonstrated that activation of Wnt/beta-catenin signaling enhanced Dkk1… CONTINUE READING