Breast cancer cells expressing stem cell markers CD44+ CD24lo are eliminated by Numb-1 peptide-activated T cells

@article{Mine2008BreastCC,
  title={Breast cancer cells expressing stem cell markers CD44+ CD24lo are eliminated by Numb-1 peptide-activated T cells},
  author={Takashi Mine and Satoko Matsueda and Yufeng Li and Hiroshi Tokumitsu and Hui Gao and Cristopher Danes and Kwong-kwok Wong and Xinhui Wang and Soldano Ferrone and Constantin G. Ioannides},
  journal={Cancer Immunology, Immunotherapy},
  year={2008},
  volume={58},
  pages={1185-1194}
}
Cancer stem cells (CSC) are resistant to chemo- and radiotherapy. To eliminate cells with phenotypic markers of CSC-like we characterized: (1) expression of CD44, CD24, CD133 and MIC-A/B (NKG2 receptors) in breast (MCF7) and ovarian (SK-OV-3) cells resistant to gemcitabine (GEM), paclitaxel (PTX) and 5-fluorouracil (5-FU) and (2) their elimination by Numb- and Notch-peptide activated CTL. The number of cells in all populations with the luminal CSC phenotype [epithelial specific antigen+ (ESA… CONTINUE READING