Breast cancer cell kinetics: immunocytochemical determination of growth fractions by monoclonal antibody Ki-67 and correlation with flow cytometric S-phase and with some features of tumor aggressiveness.

@article{Gasparini1991BreastCC,
  title={Breast cancer cell kinetics: immunocytochemical determination of growth fractions by monoclonal antibody Ki-67 and correlation with flow cytometric S-phase and with some features of tumor aggressiveness.},
  author={Giampietro Gasparini and Franco Pozza and Salvatore Meli and M E Reitano and Gianfranco Santini and Pierantonio Bevilacqua},
  journal={Anticancer research},
  year={1991},
  volume={11 6},
  pages={2015-21}
}
In operable breast cancer, cell kinetics can be utilized in the prediction of the clinical outcome of patients. The discovery of monoclonal antibodies recognizing antigens related to cell proliferation has permitted the assessment of cell kinetics by rapid and practical immunocytochemical methods. It is claimed that the Ki-67 mouse monoclonal antibody recognizes an antigen expressed in proliferating cells but not present in quiescent (G0) cells. To study the relationship between Ki-67 score and… CONTINUE READING