Breast cancer brain metastases responding to primary systemic therapy with T-DM1

@article{Bartsch2013BreastCB,
  title={Breast cancer brain metastases responding to primary systemic therapy with T-DM1},
  author={Rupert Bartsch and Anna Sophie Berghoff and Matthias Preusser},
  journal={Journal of Neuro-Oncology},
  year={2013},
  volume={116},
  pages={205-206}
}
Brain metastases are frequent in HER2-positive breast cancer and are associated with poor prognosis. Severe neurological symptoms such as neurocognitive decline, aphasia, paresis, seizures and impaired quality of life are common. The standard therapy options for brain metastases comprise local approaches such as radiotherapy, radiosurgery and neurosurgery. Novel treatments are urgently needed to improve patients’ outcomes. Recently, trastuzumab-emtansine (T-DM1), a novel antibody-cytotoxin… CONTINUE READING
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