Breast cancer, stem cells and sex hormones. Part 3: the impact of the menopause and hormone replacement.

@article{Eden2011BreastCS,
  title={Breast cancer, stem cells and sex hormones. Part 3: the impact of the menopause and hormone replacement.},
  author={John A Eden},
  journal={Maturitas},
  year={2011},
  volume={68 2},
  pages={129-36}
}
Breast stem cells are long-lived cells and so are exposed to carcinogenic influences for much longer than normal differentiated breast ductal cells. It is hypothesized that these stem cells are the major site of carcinogenesis within the breast. Epidemiological studies have suggested that early life events and early first pregnancy profoundly affect breast cancer risk in adult life. It seems likely that these observations may be, at least partially explained, through changes in stem cell number… CONTINUE READING