Breast cancer, stem/progenitor cells and the estrogen receptor.

  title={Breast cancer, stem/progenitor cells and the estrogen receptor.},
  author={Gabriela Dontu and Dorraya El-Ashry and Max S. Wicha},
  journal={Trends in endocrinology and metabolism: TEM},
  volume={15 5},
Recently, substantial progress has been made in the identification and characterization of stem and progenitor cells in the mouse and human mammary gland. Furthermore, there is accumulating evidence that these cells might be targets for transformation during mammary carcinogenesis. On the basis of this stem cell concept, we propose a model in which the transformation of different subsets of stem and progenitor cells results in the diversity of breast cancer phenotypes, including expression of… CONTINUE READING

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