Breast Osteoblast-like Cells: A Reliable Early Marker for Bone Metastases From Breast Cancer.

BACKGROUND The development of bone metastasis from breast cancer results from a functional interaction between tumor cells and osteoclasts or osteoblasts. The main aim of this study was therefore to test the hypothesis that the appearance of breast osteoblast-like cells (BOLCs) in primary mammary lesions is a precursor (and hence an early predictor) of the… (More)