Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts

@inproceedings{Liu2014BreastCS,
  title={Breast Cancer Stem Cells Transition between Epithelial and Mesenchymal States Reflective of their Normal Counterparts},
  author={Suling Liu and Yang Cong and Yu Sun and Lu Deng and Yajing Liu and Rachel Martin-Trevino and Li W. Shang and Sean P. McDermott and Melissa D. Landis and Suhyung Hong and April Adams and Rosemarie D’Angelo and Christophe Ginestier and Emmanuelle Charafe-Jauffret and Shawn G. Clouthier and Daniel Birnbaum and Stephen S T Wong and Ming Zhan and Jenny C. Chang and Max S. Wicha},
  booktitle={Stem cell reports},
  year={2014}
}
Previous studies have suggested that breast cancer stem cells (BCSCs) mediate metastasis, are resistant to radiation and chemotherapy, and contribute to relapse. Although several BCSC markers have been described, it is unclear whether these markers identify the same or independent BCSCs. Here, we show that BCSCs exist in distinct mesenchymal-like (epithelial-mesenchymal transition [EMT]) and epithelial-like (mesenchymal-epithelial transition [MET]) states. Mesenchymal-like BCSCs characterized… CONTINUE READING
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