Breast Cancer Potential through the Inhibition of Migration and Invasion in Prostate-Derived ETS Factor Is a Mediator of Metastatic

@inproceedings{Turner2007BreastCP,
  title={Breast Cancer Potential through the Inhibition of Migration and Invasion in Prostate-Derived ETS Factor Is a Mediator of Metastatic},
  author={David P. J. Turner and Omar Moussa and Moira Sauane and Paul B Fisher and Dennis K. Watson},
  year={2007}
}
Cell migration and invasion are critical events during the progression to metastasis. Without motile function, cancer cells are unable to leave the primary tumor site, invade through the basement membrane, and form secondary tumors. Expression of the epithelial-specific ETS factor prostate-derived ETS factor (PDEF) is reduced in human invasive breast tissue and lost in invasive breast cancer cell lines. Gain-of-function studies that examine different aspects of cell migration show that… CONTINUE READING

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