Breakpoints of variant 9;22 translocations in chronic myeloid leukemia locate preferentially in the CG-richest regions of the genome.

@article{Fisher2005BreakpointsOV,
  title={Breakpoints of variant 9;22 translocations in chronic myeloid leukemia locate preferentially in the CG-richest regions of the genome.},
  author={Andrew M. Fisher and Paul W Strike and Claire Scott and Anthony V Moorman},
  journal={Genes, chromosomes & cancer},
  year={2005},
  volume={43 4},
  pages={
          383-9
        }
}
From 5% to 10% of 9;22 translocations in chronic myeloid leukemia (CML) are reported to occur in variant form, that is, with the involvement of other regions of the genome in 3-way or more rearrangements. The literature indicates that the alternative breakpoints are not distributed randomly in the genome but show hotspots. We present data on 289 unpublished cases of CML with variant 9;22 translocations having a total of 342 variant breakpoints, the largest independent series to date. We found… CONTINUE READING

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