Breakpoints in the human T-cell antigen receptor α-chain locus in two T-cell leukaemia patients with chromosomal translocations

@article{Lewis1985BreakpointsIT,
  title={Breakpoints in the human T-cell antigen receptor α-chain locus in two T-cell leukaemia patients with chromosomal translocations},
  author={W. H. Peter Lewis and Effie E. Michalopoulos and Dorothy L. Williams and Mark D Minden and Tak W Mak},
  journal={Nature},
  year={1985},
  volume={317},
  pages={544-546}
}
Specific chromosomal translocations have been observed in several human and animal tumours and are believed to be important in tumorigenesis1,2. In many of these translocations the breakpoints lie near cellular homologues of transforming genes, suggesting that tumour development is partly due to the activation of these genes. The best-characterized example of such a translocation occurs in mouse plasmacytoma and human B-cell lymphoma, where c-myc, the cellular homologue of the viral oncogene… CONTINUE READING

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