Breakpoints in Robertsonian translocations are localized to satellite III DNA by fluorescence in situ hybridization.

@article{Gravholt1992BreakpointsIR,
  title={Breakpoints in Robertsonian translocations are localized to satellite III DNA by fluorescence in situ hybridization.},
  author={Claus H\ojbjerg Gravholt and Ursula Friedrich and M. Caprani and Arne Lund J\orgensen},
  journal={Genomics},
  year={1992},
  volume={14 4},
  pages={924-30}
}
We characterized 21 t(13;14) and 3 t(14;21) Robertsonian translocations for the presence of DNA derived from the short arms of the translocated acrocentric chromosomes and identified their centromeres. Nineteen of these 24 translocation carriers were unrelated. Using centromeric alpha-repeat DNA as chromosome-specific probe, we found by in situ hybridization that all 24 translocation chromosomes were dicentric. The chromatin between the two centomeres did not stain with silver, and no… CONTINUE READING

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