Breakpoint diversity illustrates distinct mechanisms for Robertsonian translocation formation.

@article{Page1996BreakpointDI,
  title={Breakpoint diversity illustrates distinct mechanisms for Robertsonian translocation formation.},
  author={Scott L. Page and Jung C. Shin and Jung Yeol Han and K. H. Choo and Lisa Gail Shaffer},
  journal={Human molecular genetics},
  year={1996},
  volume={5 9},
  pages={1279-88}
}
Robertsonian translocations are the most common chromosomal rearrangements in humans. The vast majority of the ten possible nonhomologous types of Robertsonian translocations ascertained are rob(13q14q) and rob(14q21q). Recombination between homologous sequences on nonhomologous chromosomes has been proposed as a mechanism leading to the preferential formation of rob(13q14q) and rob(14q21q). However, little evidence exists to indicate whether the remaining less common Robertsonian… CONTINUE READING
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