Breaking up of prolonged sitting over three days sustains, but does not enhance, lowering of postprandial plasma glucose and insulin in overweight and obese adults.

  title={Breaking up of prolonged sitting over three days sustains, but does not enhance, lowering of postprandial plasma glucose and insulin in overweight and obese adults.},
  author={Robyn Larsen and Bronwyn A. Kingwell and Carol Robinson and Louise Hammond and Ester Cerin and Jonathan E. Shaw and Genevieve Nissa Healy and Marc T. Hamilton and Neville Owen and David W. Dunstan},
  journal={Clinical science},
  volume={129 2},
To compare the cumulative (3-day) effect of prolonged sitting on metabolic responses during a mixed meal tolerance test (MTT), with sitting that is regularly interrupted with brief bouts of light-intensity walking. Overweight/obese adults (n=19) were recruited for a randomized, 3-day, outpatient, cross-over trial involving: (1) 7-h days of uninterrupted sitting (SIT); and (2) 7-h days of sitting with light-intensity activity breaks [BREAKS; 2-min of treadmill walking (3.2 km/h) every 20 min… 

Figures and Tables from this paper

The effects of prolonged sitting, prolonged standing, and activity breaks on vascular function, and postprandial glucose and insulin responses: A randomised crossover trial.

In normal-weight participants, Regular Activity Breaks induce increases in blood flow, shear stress and improvements in postprandial metabolism that are associated with beneficial adaptations.

Frequency of Breaks in Sedentary Time and Postprandial Metabolic Responses.

An independent effect of frequency of sedentary breaks on energy expenditure provides an explanation for the association between frequency of Sedentary breaks and adiposity observed in epidemiological data and suggests it may be necessary to break up sitting with activities of greater intensity than quiet standing to positively influence glucose, insulin, and triglyceride metabolism in relatively young, normoglycemic, overweight/obese men.

Metabolic Effect of Breaking Up Prolonged Sitting with Stair Climbing Exercise Snacks

Breaking up 9 h of prolonged sitting with hourly brief stair climbing exercise snacks lowered postprandial insulin and NEFA levels in adults with overweight/obesity.

Three weeks of interrupting sitting lowers fasting glucose and glycemic variability, but not glucose tolerance, in free-living women and men with obesity.

Under free-living conditions, FABS lowered fasting glucose and glucose variability and suggested a modest benefit for glycemic control that was most robust at higher volumes of daily activity.

Metabolic Effects of Three Different Activity Bouts during Sitting in Inactive Adults.

All three walking-bout conditions improved glycemic metabolism compared with SIT, independent of EE, in inactive, healthy adults.

Breaks in Sitting Time: Effects on Continuously Monitored Glucose and Blood Pressure

Replacing sitting with 2-min MOD walking every 20 min or 2 min of vigorous-intensity walking every hour during a simulated workday reduced 18.7 h and postprandial glucose, but only 30-minute MOD walking was effective for reducing both glucose and systolic ABP.

Effects of Interrupting Sedentary Behavior With Short Bouts of Moderate Physical Activity on Glucose Tolerance in Children With Overweight and Obesity: A Randomized Crossover Trial

Interrupting sitting with brief moderate-intensity walking improved glucose metabolism without significantly increasing energy intake in children with overweight or obesity.

Interrupting Sitting Time with Regular Walks Attenuates Postprandial Triglycerides

Regularly interrupting sitting time with brief bouts of physical activity can reduce postprandial triglyceride in postmenopausal women.

Impact of First Meal Size during Prolonged Sitting on Postprandial Glycaemia in Individuals with Prediabetes: A Randomised, Crossover Study

During periods of prolonged sitting, adults with prediabetes may have more beneficial postprandial insulin responses to a low-energy first meal.



Breaking Up Prolonged Sitting Reduces Postprandial Glucose and Insulin Responses

Interrupting sitting time with short bouts of light- or moderate-intensity walking lowers postprandial glucose and insulin levels in overweight/obese adults and may improve glucose metabolism and potentially be an important public health and clinical intervention strategy for reducing cardiovascular risk.

Breaking prolonged sitting reduces postprandial glycemia in healthy, normal-weight adults: a randomized crossover trial.

Regular activity breaks were more effective than continuous physical activity at decreasing postprandial glycemia and insulinemia in healthy, normal-weight adults.

Effects of three-day bed rest on metabolic, hormonal and circulatory responses to an oral glucose load in endurance or strength trained athletes and untrained subjects.

It is concluded that the athletes have more adequate compensation for the bed-rest-induced decrement in insulin sensitivity than sedentary men; three-day bed rest diminishes basal sympathetic activity and attenuates sympathoadrenal response to oral glucose; and endurance athletes have greater sympathetic inhibition than strength athletes or sedentaryMen.

Postprandial light physical activity blunts the blood glucose increase.

Breaks in Sedentary Time

Evidence is provided of the importance of avoiding prolonged uninterrupted periods of sedentary (primarily sitting) time and new public health recommendations regarding breaking up sedentary time that are complementary to those for physical activity are suggested.

Seven days of bed rest decrease insulin action on glucose uptake in leg and whole body.

7 days of bed rest decrease whole body insulin action, a fact that is explained by decreased insulin action in inactive muscle in normal humans after short-term bed rest.

Effects of 3-day bed rest on physiological responses to graded exercise in athletes and sedentary men.

Reduction of exercise performance and modifications in neurohormonal response to exercise after BR depend on the previous level and mode of physical training, being the most pronounced in the endurance athletes.

Metabolic response of normal man and insulin-infused diabetics to postprandial exercise.

The diabetic responses to closed-loop insulin infusion provide important data in defining the appropriate preprogrammed open- loop insulin infusion pattern for postprandial exercise.