Breaking the symmetry: immune enhancement increases persistence of dengue viruses in the presence of asymmetric transmission rates.

@article{MieryTeranRomero2013BreakingTS,
  title={Breaking the symmetry: immune enhancement increases persistence of dengue viruses in the presence of asymmetric transmission rates.},
  author={Luis Mier-y-Teran-Romero and Ira B. Schwartz and Derek A. T. Cummings},
  journal={Journal of theoretical biology},
  year={2013},
  volume={332},
  pages={
          203-10
        }
}
The dengue viruses exist as four antigenically distinct serotypes. These four serotypes co-circulate and interact with each other through multiple immune-mediated mechanisms. Though the majority of previous efforts to understand the transmission dynamics of dengue have assumed identical characteristics for these four serotypes, empirical data suggests that they differ from one another in important ways. Here, we examine dynamics and persistence in models that do not assume symmetry between the… CONTINUE READING
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