Breaking symmetries: regulation of Dictyostelium development through chemoattractant and morphogen signal-response.

@article{Kimmel2004BreakingSR,
  title={Breaking symmetries: regulation of Dictyostelium development through chemoattractant and morphogen signal-response.},
  author={Alan R. Kimmel and Richard A. Firtel},
  journal={Current opinion in genetics & development},
  year={2004},
  volume={14 5},
  pages={540-9}
}
Dictyostelium discoideum grow unicellularly, but develop as multicellular organisms. At two stages of development, their underlying symmetrical pattern of cellular organization becomes disrupted. During the formation of the multicellular aggregate, individual non-polarized cells re-organize their cytoskeletal structures to sequester specific intracellular signaling elements for activation by and directed movement within chemoattractant gradients. Subsequently, response to secreted morphogens… CONTINUE READING