Breaking of CD8/sup +/ T-cell anergy through in vivo ligation of GITR

  • B. Kwon
  • Published 2005 in
    Proceedings. The 9th Russian-Korean International…
Peripheral T-cell anergy is an important tolerance mechanism. Using a murine model of chronic systemic lupus erythematosus (SLE)-like graft-versus-host disease (cGVHD), we demonstrate that donor CD8/sup +/ T cells rapidly become hyporesponsive in the recipient mouse. Further we find that a single dose of an agonistic antibody against GITR, a member of the… (More)