Breaking down the complement system: a review and update on novel therapies.

@article{Reddy2017BreakingDT,
  title={Breaking down the complement system: a review and update on novel therapies.},
  author={Yuvaram N V Reddy and Andrew M. Siedlecki and Jean M. Francis},
  journal={Current opinion in nephrology and hypertension},
  year={2017},
  volume={26 2},
  pages={
          123-128
        }
}
PURPOSE OF REVIEW The complement system represents one of the more primitive forms of innate immunity. It has increasingly been found to contribute to pathologies in the native and transplanted kidney. We provide a concise review of the physiology of the complement cascade, and discuss current and upcoming complement-based therapies. RECENT FINDINGS Current agents in clinical use either bind to complement components directly or prevent complement from binding to antibodies affixed to the… CONTINUE READING