Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders
@article{Kelly2015BreakingDT,
title={Breaking down the barriers: the gut microbiome, intestinal permeability and stress-related psychiatric disorders},
author={John R. Kelly and Paul J Kennedy and John F. Cryan and Timothy G. Dinan and Gerard Clarke and Niall P. Hyland},
journal={Frontiers in Cellular Neuroscience},
year={2015},
volume={9},
url={https://api.semanticscholar.org/CorpusID:17713012}
}This review will discuss the possible role played by the gut microbiota in maintaining intestinal barrier function and the CNS consequences when it becomes disrupted, and draw on both clinical and preclinical evidence to support this concept.
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337 References
The microbiota–gut–brain axis in gastrointestinal disorders: stressed bugs, stressed brain or both?
- 2014
Medicine, Biology
The literature on the role of gut microbiota in gut homeostasis is reviewed and the association of dysbiosis with disease is discussed, with particular focus on functional bowel disorders and their relationship to psychological stress.
The microbiome: stress, health and disease
- 2013
Medicine, Biology
The concept of a microbiome–brain–gut axis is emerging which suggests that modulation of the gut microflora may be a tractable strategy for developing novel therapeutics for complex stress-related CNS disorders where there is a huge unmet medical need.
Brain–Gut–Microbe Communication in Health and Disease
- 2011
Medicine, Biology
The evidence supporting a role for the enteric flora in brain–gut axis disorders is explored with the spotlight on the clinical relevance for irritable bowel syndrome, a stress-related functional gastrointestinal disorder.
Gut Microbes and the Brain: Paradigm Shift in Neuroscience
- 2014
Medicine, Biology
O Ongoing large-scale population-based studies of the gut microbiome and brain imaging studies looking at the effect of gut microbiome modulation on brain responses to emotion-related stimuli are seeking to validate speculations.
Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour
- 2012
Biology, Medicine
The emerging concept of a microbiota–gut–brain axis suggests that modulation of the gut microbiota may be a tractable strategy for developing novel therapeutics for complex CNS disorders.
The effects of inflammation, infection and antibiotics on the microbiota-gut-brain axis.
- 2014
Medicine, Biology
The concept of microbiota-gut-brain interactions opens a new field of research aimed at developing microbial-directed therapies to treat a broad spectrum of human conditions, including chronic gastrointestinal and psychiatric disorders.
Serotonin, tryptophan metabolism and the brain-gut-microbiome axis
- 2015
Medicine, Biology
The microbiota-gut-brain axis in functional gastrointestinal disorders
- 2014
Biology, Environmental Science
This review aims to recapitulate the available literature on FGIDs and microbiota-gut-brain axis and finds patients with Irritable Bowel Syndrome display altered composition of the gut microbiota compared with healthy controls and benefit, at the gastrointestinal and psychological levels, from the use of probiotics and antibiotics.
Melancholic microbes: a link between gut microbiota and depression?
- 2013
Medicine, Biology
Evidence is demonstrated that there is a distinct perturbation of the composition of gut microbiota in animal models of depression and chronic stress, which has direct implications for the development of psychobiotic‐based therapeutic strategies for psychiatric disorders.
Principles and clinical implications of the brain–gut–enteric microbiota axis
- 2009
Medicine, Biology
Enterochromaffin cells are important bidirectional transducers that regulate communication between the gut lumen and the nervous system, and may have an important role in pain and immune-response modulation, control of background emotions and other homeostatic functions.




