Breaking boundaries—coagulation and fibrinolysis at the neurovascular interface

  title={Breaking boundaries—coagulation and fibrinolysis at the neurovascular interface},
  author={Sophia Bardehle and Victoria A. Rafalski and Katerina Akassoglou},
  booktitle={Front. Cell. Neurosci.},
Blood proteins at the neurovascular unit (NVU) are emerging as important molecular determinants of communication between the brain and the immune system. Over the past two decades, roles for the plasminogen activation (PA)/plasmin system in fibrinolysis have been extended from peripheral dissolution of blood clots to the regulation of central nervous system (CNS) functions in physiology and disease. In this review, we discuss how fibrin and its proteolytic degradation affect neuroinflammatory… CONTINUE READING
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