Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis. Pathogenetic and clinical implications.

@article{Kermode1990BreakdownOT,
  title={Breakdown of the blood-brain barrier precedes symptoms and other MRI signs of new lesions in multiple sclerosis. Pathogenetic and clinical implications.},
  author={Allan G. Kermode and Alan J. Thompson and Paul S. Tofts and David G. MacManus and Brian E. Kendall and David E. Kingsley and Ivan F. Moseley and Peter Rudge and W. Ian McDonald},
  journal={Brain : a journal of neurology},
  year={1990},
  volume={113 ( Pt 5)},
  pages={1477-89}
}
From an extensive serial magnetic resonance imaging (MRI) study in multiple sclerosis (MS) we have identified 4 cases in which disruption of the blood-brain barrier, as detected by gadolinium-DTPA enhancement, preceded other MRI abnormalities and in 1 case clinical evidence of the new lesion. This supports the view that a defect in the blood-brain barrier, and therefore inflammation, is an early and possibly crucial event in the pathogenesis of the new lesion in MS. These cases showed a marked… CONTINUE READING
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