Breakdown of C3 after complement activation. Identification of a new fragment C3g, using monoclonal antibodies

@article{Lachmann1982BreakdownOC,
  title={Breakdown of C3 after complement activation. Identification of a new fragment C3g, using monoclonal antibodies},
  author={Peter J. Lachmann and Michael K. Pangburn and Rodney G Oldroyd},
  journal={The Journal of Experimental Medicine},
  year={1982},
  volume={156},
  pages={205 - 216}
}
The physiological breakdown of C3 has been studied using monoclonal anti-C3 antibodies, and it has been found that the later stages of this process--the breakdown of C3bi--is more complex than had previously been recognized. C3bi is the reaction product produced from C3b by the action of factor I which, in the presence of factor H, produces a double cleavage in the alpha chain of C3b. It is here reported that, both on cells and in the fluid phase, the breakdown of C3bi in serum gives rise to… CONTINUE READING

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Release of C3 from bound C3bi by C3b inactivator

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