Break-points on a progressive ratio schedule reinforced by intravenous cocaine increase following depletion of forebrain serotonin

@article{Loh1990BreakpointsOA,
  title={Break-points on a progressive ratio schedule reinforced by intravenous cocaine increase following depletion of forebrain serotonin},
  author={Elliot A. Loh and David C. S. Roberts},
  journal={Psychopharmacology},
  year={1990},
  volume={101},
  pages={262-266}
}
The effect of intracerebral injections of 5,7-dihydroxy-tryptamine (5,7-DHT) on cocaine self-administration behavior was assessed. Rats were tested on a progressive ratio (PR) schedule for cocaine reinforcement. The first response on the lever each day produced an IV infusion of cocaine (0.6 mg/injection) after which the requirements of the schedule escalated with each reinforcement until the behavior extinguished. The final ratio completed was defined as the breaking point. Bilateral… CONTINUE READING

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