Break induced replication in eukaryotes: mechanisms, functions, and consequences.

@article{Sakofsky2017BreakIR,
  title={Break induced replication in eukaryotes: mechanisms, functions, and consequences.},
  author={Cynthia J. Sakofsky and Anna Malkova},
  journal={Critical reviews in biochemistry and molecular biology},
  year={2017},
  volume={52 4},
  pages={
          395-413
        }
}
Break-induced replication (BIR) is an important pathway specializing in repair of one-ended double-strand DNA breaks (DSBs). This type of DSB break typically arises at collapsed replication forks or at eroded telomeres. BIR initiates by invasion of a broken DNA end into a homologous template followed by initiation of DNA synthesis that can proceed for hundreds of kilobases. This synthesis is drastically different from S-phase replication in that instead of a replication fork, BIR proceeds via a… CONTINUE READING
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