Break-induced loss of heterozygosity in fission yeast: dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition.

@article{Cullen2007BreakinducedLO,
  title={Break-induced loss of heterozygosity in fission yeast: dual roles for homologous recombination in promoting translocations and preventing de novo telomere addition.},
  author={Jason K Cullen and Sharon P Hussey and Carol Walker and John Prudden and Boon-Yu Wee and Anoushka Dav{\'e} and James S Findlay and Andrew P Savory and Timothy Humphrey},
  journal={Molecular and cellular biology},
  year={2007},
  volume={27 21},
  pages={7745-57}
}
Loss of heterozygosity (LOH), a causal event in tumorigenesis, frequently encompasses multiple genetic loci and whole chromosome arms. However, the mechanisms leading to such extensive LOH are poorly understood. We investigated the mechanisms of DNA double-strand break (DSB)-induced extensive LOH by screening for auxotrophic marker loss approximately 25 kb distal to an HO endonuclease break site within a nonessential minichromosome in Schizosaccharomyces pombe. Extensive break-induced LOH was… CONTINUE READING

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