Break dosage, cell cycle stage and DNA replication influence DNA double strand break response

@article{Zierhut2008BreakDC,
  title={Break dosage, cell cycle stage and DNA replication influence DNA double strand break response},
  author={Christian Zierhut and John F X Diffley},
  journal={The EMBO Journal},
  year={2008},
  volume={27},
  pages={1875 - 1885}
}
DNA double strand breaks (DSBs) can be repaired by non-homologous end joining (NHEJ) or homology-directed repair (HR). HR requires nucleolytic degradation of 5' DNA ends to generate tracts of single-stranded DNA (ssDNA), which are also important for the activation of DNA damage checkpoints. Here we describe a quantitative analysis of DSB processing in the budding yeast Saccharomyces cerevisiae. We show that resection of an HO endonuclease-induced DSB is less extensive than previously estimated… CONTINUE READING
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