Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells

@article{Costantino2014BreakInducedRR,
  title={Break-Induced Replication Repair of Damaged Forks Induces Genomic Duplications in Human Cells},
  author={Lorenzo Costantino and Sotirios K. Sotiriou and Juha K. Rantala and Simon Magin and Emil Mladenov and Thomas Helleday and James E Haber and George Iliakis and Olli Kallioniemi and Thanos D Halazonetis},
  journal={Science},
  year={2014},
  volume={343},
  pages={88-91}
}
In budding yeast, one-ended DNA double-strand breaks (DSBs) and damaged replication forks are repaired by break-induced replication (BIR), a homologous recombination pathway that requires the Pol32 subunit of DNA polymerase delta. DNA replication stress is prevalent in cancer, but BIR has not been characterized in mammals. In a cyclin E overexpression model of DNA replication stress, POLD3, the human ortholog of POL32, was required for cell cycle progression and processive DNA synthesis… CONTINUE READING
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  • R. Beroukhim et al., Nature 463, 899–905 . Acknowledgments
  • Bartek for the U2OS cells inducibly…
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