Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter.

@article{Wood2003Bre1AE,
  title={Bre1, an E3 ubiquitin ligase required for recruitment and substrate selection of Rad6 at a promoter.},
  author={Adam L. Wood and Nevan J. Krogan and Jim Dover and Jessica R. Schneider and Jonathan Heidt and Marry Ann Boateng and Kimberly M. Dean and Ashkan Golshani and Yi Zhang and Jack Greenblatt and Mark Johnston and Ali Shilatifard},
  journal={Molecular cell},
  year={2003},
  volume={11 1},
  pages={267-74}
}
Ubiquitination of histone H2B catalyzed by Rad6 is required for methylation of histone H3 by COMPASS. We identified Bre1 as the probable E3 for Rad6's role in transcription. Bre1 contains a C3HC4 (RING) finger and is present with Rad6 in a complex. The RING finger of Bre1 is required for ubiquitination of histone H2B, methylation of lysine 4 and 79 of H3 and for telomeric silencing. Chromatin immunoprecipitation experiments indicated that both Rad6 and Bre1 are recruited to a promoter. Bre1 is… CONTINUE READING
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