Brd4 links chromatin targeting to HPV transcriptional silencing.

@article{Wu2006Brd4LC,
  title={Brd4 links chromatin targeting to HPV transcriptional silencing.},
  author={S y Wu and A-young Lee and Samuel Y Hou and Jongsook Kim Kemper and Hediye Erdjument-Bromage and Paul Tempst and C. -S. Chiang},
  journal={Genes & development},
  year={2006},
  volume={20 17},
  pages={2383-96}
}
The E2 protein encoded by human papillomaviruses (HPVs) inhibits expression of the viral E6 oncoprotein, which, in turn, regulates p53 target gene transcription. To identify cellular proteins involved in E2-mediated transcriptional repression, we isolated an E2 complex from human cells conditionally expressing HPV-11 E2. Surprisingly, the double bromodomain-containing protein Brd4, which is implicated in cell cycle control and viral genome segregation, was found associated with E2 and conferred… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 82 extracted citations

The papillomavirus E2 proteins.

Virology • 2013
View 7 Excerpts
Highly Influenced

The Bromodomain and Extra-Terminal Domain (BET) Family: Functional Anatomy of BET Paralogous Proteins

International journal of molecular sciences • 2016
View 3 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 52 references

The general transcription machinery and general cofactors.

Critical reviews in biochemistry and molecular biology • 2006

Similar Papers

Loading similar papers…