Brd4 links chromatin targeting to HPV transcriptional silencing.

  title={Brd4 links chromatin targeting to HPV transcriptional silencing.},
  author={S y Wu and A-young Lee and Samuel Y Hou and Jongsook Kim Kemper and Hediye Erdjument-Bromage and Paul Tempst and C. -S. Chiang},
  journal={Genes & development},
  volume={20 17},
The E2 protein encoded by human papillomaviruses (HPVs) inhibits expression of the viral E6 oncoprotein, which, in turn, regulates p53 target gene transcription. To identify cellular proteins involved in E2-mediated transcriptional repression, we isolated an E2 complex from human cells conditionally expressing HPV-11 E2. Surprisingly, the double bromodomain-containing protein Brd4, which is implicated in cell cycle control and viral genome segregation, was found associated with E2 and conferred… CONTINUE READING


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