Brd4 Is Essential for IL-1β-Induced Inflammation in Human Airway Epithelial Cells

@inproceedings{Khan2014Brd4IE,
  title={Brd4 Is Essential for IL-1β-Induced Inflammation in Human Airway Epithelial Cells},
  author={Younis M. Khan and Paul Kirkham and Peter J Barnes and Ian M. Adcock},
  booktitle={PloS one},
  year={2014}
}
BACKGROUND Chronic inflammation and oxidative stress are key features of chronic obstructive pulmonary disease (COPD). Oxidative stress enhances COPD inflammation under the control of the pro-inflammatory redox-sensitive transcription factor nuclear factor-kappaB (NF-κB). Histone acetylation plays a critical role in chronic inflammation and bromodomain and extra terminal (BET) proteins act as "readers" of acetylated histones. Therefore, we examined the role of BET proteins in particular Brd2… CONTINUE READING
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