Brazilin induces apoptosis and G2/M arrest via inactivation of histone deacetylase in multiple myeloma U266 cells.

@article{Kim2012BrazilinIA,
  title={Brazilin induces apoptosis and G2/M arrest via inactivation of histone deacetylase in multiple myeloma U266 cells.},
  author={Bonglee Kim and Sun-Hee Kim and Soo-Jin Jeong and Eun Jung Sohn and Ji Hoon Jung and Min Ho Lee and Sung-Hoon Kim},
  journal={Journal of agricultural and food chemistry},
  year={2012},
  volume={60 39},
  pages={9882-9}
}
Although brazilin [7,11b-dihydrobenz(b)indeno[1,2-d]pyran-3,6a,9,10(6H)-tetrol] isolated from Caesalpinia sappan was known to have various biological activities, including anti-inflammation, antibacteria, and antiplatelet aggregation, there is no report yet on its anticancer activity. In the present study, the anticancer mechanism of brazilin was elucidated in human multiple myeloma U266 cells. We found that brazilin significantly inhibited the activity of histone deacetylases (HDACs… CONTINUE READING
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